Jesus looked around at the Jewish Leaders with anger, deeply distressed at their stubborn hearts. - Mark 3:5.
The pursuit of Christian truth is concerned about what Mark 3:5 is trying to tell us within the context of Isaiah 45:7 and Isaiah 6:9-10.
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The only indication in Mark 3:5 is that Jesus was angry at the leadership for having hard hearts concerning the well being of the crippled man. Their only interest was in trapping the Lord and accusing Him and they cared not even the slightest for the suffering of their fellow man. This is clearly seen in that, having witnessed the miraculous healing of the man right before their very eyes, they immediately counseled together with other wicked men (Herodians) on how to destroy Jesus.
Again he entered the synagogue, and a man was there with a withered hand. And they watched Jesus, to see whether he would heal him on the Sabbath, so that they might accuse him. And he said to the man with the withered hand, “Come here.” And he said to them, “Is it lawful on the Sabbath to do good or to do harm, to save life or to kill?” But they were silent. And he looked around at them with anger, grieved at their hardness of heart, and said to the man, “Stretch out your hand.” He stretched it out, and his hand was restored. The Pharisees went out and immediately held counsel with the Herodians against him, how to destroy him. - Mark 3:1-6
There is nothing in this passage to suggest that Jesus was angry with God. In fact Jesus, the eternal Son come in the flesh, was well aware from the foundation of the earth that he was to come into a world of enmity and be rejected, mistreated, persecuted, scourged, and crucified:
“The hour has come for the Son of Man to be glorified. Truly, truly, I say to you, unless a grain of wheat falls into the earth and dies, it remains alone; but if it dies, it bears much fruit. Whoever loves his life loses it, and whoever hates his life in this world will keep it for eternal life. If anyone serves me, he must follow me; and where I am, there will my servant be also. If anyone serves me, the Father will honor him. “Now is my soul troubled. And what shall I say? ‘Father, save me from this hour’? But for this purpose I have come to this hour. Father, glorify your name.” - John 12:23-28