The 2 passages quoted for the comparison need to be understood in the context of what happened in Genesis.
GEN 3:7 Then the eyes of both of them were opened,
And, as we work to understand this passage we need to step back out of Genesis.
2 KINGS 6:17 And Elisha prayed, and said, “Lord, I pray, open his eyes that he may see.” Then the Lord opened the eyes of the young man, and he saw.
Let’s step through this. First, Adam and Eve could ‘see’ prior to eating. Eve ‘saw’ the tree and ‘saw’ that it was good for food. So what does it mean when it says their ‘eyes’ were ‘opened’? This is a crucial answer, because this happened as a result of the Serpents intervention. And since then we have this …
2 COR 4:4 whose minds the god of this age has blinded,
So the god of this world has blinded ‘man’. But we just ‘saw’ where - In the garden, but that account said their eyes were opened? But …
MAT 13:13 Therefore I speak to them in parables, because seeing they do not see,
Now consider this with the passage from John which you quoted, which is a quote from Isaiah 6. And relate that to our passage above from Kings. The servant could see - but it was his spiritual eyes that couldn’t. John out of all the gospels arguably looks more at the ‘spiritual’ dimension of ‘believers’.
The whole gospel is 100% directed at ‘man’s’ heart, that is, his ‘spirit’. And it’s man’s ‘spiritual’ eyes and ears that need to hear/see. But Satan has ‘blinded’ man’s spirit by separating it from God - (in the garden). Since then, man has been directed purely via his natural (physical) ears/ears (senses, i.e. carnal [flesh/sax]).
This because of the serpent - he blinded man’s (spiritual) eyes. (2 Corinthians 4:4). That’s why the Holy Spirit is essential for new birth. It’s man’s ‘spirit’ that needs to be reached. And without using your ‘spiritual eyes’, you are ‘blind’ (to the truth) (John 12:40).