This question actually addresses a very important point. To fully address this point would take more space than answers allow, so I will only outline the answer ...
It starts with seeds.
GEN 1:29 And God said, “See, I have given you every herb that yields seed which is on the face of all the earth, and every tree whose fruit yields seed; to you it shall be for food.
The ‘seed’ is the primary element for physical life. In fact, for everything. Everything on this earth originates from a seed. Everything!
But note the number of times God said that life reproduces ‘according to its kind’. This was Gods design.
Since creation, God has not [needed to] created a single additional thing. He didn’t need to create some more fruit trees because more people came along, nor did he [need to] create more people. All because of seed. Seed is crucial - which is why the principle of sowing and reaping is important to understand. And, the concept of ‘seeds’ will be in effect as long as the earth exists - because it ‘runs/drives’ the earth.
But, for the ‘earth/life’ to ‘run’ by design, as intended, in some respects ‘righteously’, seed should notbe mixed. Everything should remain within its ‘own kind’.
GEN 8:22 ”While the earth remains, Seedtime and harvest, Cold and heat, Winter and summer, And day and night Shall not cease.”
Now, if you start mixing ‘seeds’, you start no longer producing after your own kind, you then start getting mixture. That was the issue here ...
GEN 6:4 There were giants on the earth in those days, and also afterward, when the sons of God came in to the daughters of men and they bore children to them.
We learn this from the non-canonical book Enoch 1. Although non-canonical, the Jews at the time of Jesus were all familiar with the content of this book. Fragments have been found amongst the Dead Sea findings, and both Peter and James quote from it. Enoch 1 talks about ‘seed mixing’, genetically modifying both plant and animal. That’s where the ‘unclean’ animals originate - genetically mixing different ‘kinds’.
So the result of mixing seed is unclean. And we know Gods reaction to anything unclean by scripture. For example, Jews were forbidden to eat anything unclean. Some argue that the reason for the flood was to deal with genetically modified ‘hybrids’.
So, despite this only being an overview, the answer to your question “Is the creation of certain hybrids ok?” should be clear.