Background to response
If you are to consider the possibility of Genesis 6 as being true and accurate, namely that the sons of God copulated with human women in order that they might corrupt the human seed (genome) and thereby destroy the possibility of a redeemer as prophecied that would restore humans back into right standing with God
“I will put enmity between you and the woman, and between your offspring and her offspring; he shall bruise your head, and you shall bruise his heel."”
Genesis 3:15
(Notice both the woman and the deceiver have seed)
And that the seed of the sons of God survived the flood through Ham’s wife and child Canaan cursed by Noah
And that God decided after the nations rebelled against The God of heaven, to put over them gods to rule over them as they were divided Deu 32:8 LLX and Psalm 82
But God made His own nation from Abraham by the son of promise Isaac Deu 32:9 and Deu 7:7 the youngest and therefore the fewest of all the nations
If you believe that God had a specific plan and therefore a particular bloodline lineage through which He would bring the Messiah into the world then it will make complete sense why Esau was hated.
Esau and his genome
The passage in Romans does not deal with Salvific predestination but with a linage choice through which the messiah would come. You have to read into the text salvation of the soul because it’s simply not there.
“To them belong the patriarchs, and from their race, according to the flesh, is the Christ, who is God over all, blessed forever. Amen.”
Romans 9:5
Obviously salvation in the New Covenant which makes the Old Covenant obsolete does not come by way of bloodlines John 1:13
Because not everyone born of blood is Israel (Part of the New Commonwealth of Israel or God’s Israel)
“But it is not as though the word of God has failed. For not all who are descended from Israel belong to Israel, and not all are children of Abraham because they are his offspring, but "Through Isaac shall your offspring be named." This means that it is not the children of the flesh who are the children of God, but the children of the promise are counted as offspring. For this is what the promise said: "About this time next year I will return, and Sarah shall have a son."”
Romans 9:6-9
This child Isaac was promised, Ishmael was a shadow of the child of the flesh a mixture between Abraham the righteous and Hagar the Egyptian or a type for the world/carnal.
Context
But it’s in this context of bloodlines and promised children concerning a promised Messiah that hatred for Esau is illustrated.
“And not only so, but also when Rebekah had conceived children by one man, our forefather Isaac, though they were not yet born and had done nothing either good or bad—in order that God's purpose of election might continue, not because of works but because of him who calls— she was told, "The older will serve the younger." As it is written, "Jacob I loved, but Esau I hated."”
Romans 9:10-13
This hatred occurred at the moment of conception. And God does not do thing arbitrarily. So there is something that distinguishes Esau from Jacob. We know Isaac was a child of promise from parents God had chosen and we might argue from the Hebrew word they were tamaiym. But Rebecca we have no reason to believe she was tamaiym. Especially since of the two children she has one (Esau) has corrupted 🧬 DNA.
Genetic phenotypes
We can know what Esau looked like because Jacob through his mother impersonates Esau’s appearance.
“And the skins of the young goats she put on his hands and on the smooth part of his neck.”
Genesis 27:16
Firstly Esau was red
“The first came out red, ALL his body like a hairy cloak, so they called his name Esau.”
Genesis 25:25
Secondly he was completely covered in hair not from puberty but from birth.
This means based on other passages that Esau carried in his genome the seed of the deceiver or of his counterparts the sons of God that copulated with human women.
Humans are not born like animals with hair all over and humans on the smooth of the neck where there is no hair DON’T have hair that is the same as a young goats hair.
Conslusion
Esau was hated or not chosen by God from the moment of conception because he unfortunately inherited seed from the sons of God passed into by the Nephilim onto Ham’s wife, Canaan the child and transmitted to Rebecca who gave rise to a Nephilim child Esau and a non Nephilim human child Jacob. The choice was obvious at this point why Jacob was favored purely for his genetic purity tamaiym-ness.