Yes, the plagues sent by God upon the Egyptians were aimed at many of their gods. The purpose was to show how impotent the gods of Egypt were and to force the Pharaoh to let God’s people go.
Exodus 7:14-24 describes how the river Nile was changed into blood, also affecting the streams, canals, ponds and all the reservoirs. The fish died and the water was undrinkable. This, the first plague, was directed at Apis, the god of the Nile, Isis, the goddess of the Nile, and Khnum, guardian of the Nile. The Egyptians believed the Nile was the bloodstream of Osiris, who was reborn each year when the river flooded.
The second plague was delivered seven days later, and is described in Exodus 8:1-15. The plague of frogs (which came from the Nile), was a judgment against Heqet, the frog-headed goddess of birth. Frogs were thought to be sacred. After the frogs died, their stinking bodies were heaped up in offensive piles all through the land (Exodus 8:13–14).
The third plague of gnats was a judgment on Set, the god of the desert. Unlike the previous plagues, the Egyptian magicians were unable to duplicate this one and said to Pharaoh, “This is the finger of God” (Exodus 8:19).
Exodus 8:20-32 describes how the fourth plague, swarms of flies, afflicted only the Egyptians. God’s people, who lived in Goshen, were excluded. This was a judgment on Uatchit, the fly god.
The fifth plague, the death of livestock, was a judgment on the goddess Hathor and the god Apis, who were both depicted as cattle. Exodus 9:1-7 describes how God’s people were unaffected.
The sixth plague, boils, as described in Exodus 9:8-12, was a judgment against Sekhmet, Sunu, and Isis who were ascribed with powers to prevent disease.
There followed a spectacular and dramatic seventh plague, of thunder, hail and lightning. This plague was directed against Nut, the sky goddess, Osiris, the crop fertility god, and Set, the storm god. Exodus 9:13-35 describes the utter devastation of crops, men and beasts, and trees. But no hail fell in the land of Goshen, where the Israelites were.
God wasn’t done with Nut (the sky goddess), Osiris (the crop fertility god) and Set (the storm god). Exodus 10:12-20 describes how a plague of locusts devoured the remaining crops of wheat and rye, ensuring there would be no harvest in Egypt that year.
The ninth plague is described in Exodus 10:21-29. The three days of darkness was aimed at the sun-god, Ra (or Re), one of the chief deities of Egypt. Ra was symbolized by Pharaoh himself.
Exodus chapter 11 describes the tenth and last plague, the death of the firstborn Egyptian males, which was a judgment on Isis, the protector of children. This was the ultimate disaster since all the plans and dreams of a father were bound up in his firstborn son.
The New International Study Bible notes explain how the first, the fourth and seventh plagues were introduced by a warning, delivered to the Pharaoh in the morning as he went out to the Nile. He and his gods were powerless in the face of the creator, who exposed those false gods as impotent.