"These are they who have not defiled themselves by relations with women, for they are [[c]pure as] virgins."
They are not males (144,000) as most of us generally think. They are virgins but not defiled by women. The difference is women mean a group of women married to husbands, a virgin not married to anyone. So, these 144,000 virgins are not defiled by others who are married to some other husbands but not Jesus.
"These were redeemed from among men, being the first fruits unto God and to the Lamb." In a relationship, the first and foremost relationship is husband and wife.
The Holy Spirit can be equated with the wife of Father God. Here the wife means nothing about gender, but about the relationship. Father God and Mother God (Holy Spirit) can never be separated. There are 100s of Bible verses to support this.
So, the first relationship in the God family itself is Father God and Holy Spirit. Sons and daughters come next. So, these virgins (144,000) are the body (executive member) of Jesus Christ, like Holy Spirit to Father God. Father God always acts through Holy Spirit only, likewise, Jesus will act through these 144,000 virgins (first fruits) only, how we act only through our physical body.
Now, about the women, their primary nature is to defile others. That's why Bible says not defiled by women. These women are having their own husbands but not Jesus Christ. Yes, as their husbands are either the devil/Satan or his angels, their primary nature has become defiling others.