Friends or Family?
καὶ ἀκούσαντες οἱ παρ' αὐτοῦ ἐξῆλθον κρατῆσαι αὐτόν· ἔλεγον γὰρ ὅτι
ἐξέστη( Mark 3:21 Textus Receptus Stephanus 1550)
"And having heard (of it), those belonging to him went out to seize him they said indeed he is out of his mind."(Interlinear translation)
The "οἱ παῥ αὐτοῦ," (those of one's family, i. e. his kinsmen, relations),(from Thayer's Lexicon), indicates more than the KJV, which says,"And when his friends heard of it." This also is confirmed by the previous statement, μὴ δύνασθαι αὐτοὺς μήτε ἄρτον φαγεῖν(not they are even able them even bread to eat)(vs 20), it is Jesus and His disciples, and not merely Jesus who is regarded "out of their mind" or "besides themselves".
This is an important distinction, because in this passage there are numerous issues to be considered "out of one's mind" about. There are the throngs, who've so crowded Jesus and His disciples, and there are the scribes and Pharisees, who have accused Him of casting out demons by Beelzebub, the "prince" of demons.(vss 22-27)
The "κρατῆσαι"(to seize) Him, could be extrapolated as "doubt" about His ministry; "κρατῆσαι"(kratos-to rule) which is the root word of "kratesai"(to seize), which appeared to be the intention of his mother and family. But notice how Jesus deflects their concerns, and yet assures them of His control.(vss 31-35)
There came then his brethren and his mother, and, standing without,
sent unto him, calling him. 32And the multitude sat about him, and
they said unto him, Behold, thy mother and thy brethren without seek
for thee. 33And he answered them, saying, Who is my mother, or my
brethren? 34And he looked round about on them which sat about him, and
said, Behold my mother and my brethren! 35For whosoever shall do the
will of God, the same is my brother, and my sister, and mother.
He reminds His mother again(Luke 2:49)
And he said unto them, How is it that ye sought me? wist ye not that I
must be about my Father's business?
And yet He declares that those who do His Father's will are also His Family. This rebuke sets His family straight about His Father's business, yet assures them that He hasn't disowned them, He's invited them into a 'larger family' of those who do His Father's Will.
Mary pondered both Jesus's and the angel's words in her heart(Luke 1); she certainly knew His destiny. It appears from vs 20-21 she was concerned about His physical wellbeing, but was assured again(vs33-35) He was doing the Will of the Father, and would not be dissuaded from it. Her next course of action was to be a "woman of faith" who would also do the Will of His Heavenly Father.