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I think the "meaning" of this word in the context is that Yahweh (God) will lift the curse from the ground. The thorns and thistles (nettles) are the result of the curse on the ground. Isaiah is prophesying that there will be a time when these products of the curse of the ground will be removed, and then substituted with "living" plants that actually bear ...

I guess we are into Bible trivia here but it is an unidentified desert plant. It apparently comes from the root word סָרַף which means to burn. Therefore it was probably a prickly bush/plant that 'burned' when one was pricked by it. It is not used anywhere else in the Bible.