To summarize what Mark Anthony Songer said, wisdom and spiritual insight are good, but they are not sufficient for seeing the "big picture" in the same way God does. His ways and thoughts are so often beyond us, which is why we are told that the better part of wisdom is simply to hold Him in reverential fear, even when satisfying answers from Him are not forthcoming.
As a preacher I heard recently said,
"God may answer your prayer with a no; He may answer it quickly; He may answer it later; or He may answer it better."
In the case of Job, God's answer to his prayers and heart cries for additional wisdom and insight were "later" and "better." Furthermore, God didn't really answer Job's most burning questions; rather, He told Job in essence, "You need to have a little more reverential fear of me. Period." In his own way, Job was guilty of condemning God to justify himself. God asked Job,
"'Will you really annul My judgment?
Will you condemn Me that you may be justified?'" (40:8)
To justify and rationalize is the hallmark of fallen humanity, and Job--as with all of us--was a part of fallen humanity. He was blameless, yes, but sinless, no. When we struggle to understand why God has sent hard times our way, He often comes right back at us with His answer, but in the form of a question:
After all, does the clay say to the potter, "Why do you shape me the way you do? You seem to want me to be an ordinary vase, but I want to be a splendid piece of art! Can't you see I'm destined for better things? Don't you realize . . .?" In other words, the clay condemns the potter to justify its version for how it envisions things ought to be. That's not how things work, however, as the potter has the last word as to what is made and how. So too with God, He is the potter; we are the clay (see Jeremiah 18:1-6 and Romans 9:20-24).
Isaiah 55:8,9 summarize quite nicely what Job learned the hard way:
"'For My thoughts are not your thoughts,
Nor are your ways My ways,' declares the LORD.
'For as the heavens are higher than the earth,
So are My ways higher than my ways
And My thoughts than your thoughts.'"
In conclusion, we know that Job learned the lesson God was teaching him because he repented in dust and ashes (Job 42:6). God expects the same reaction of us today when He tries to teach us a hard lesson and we rebel and start to think we know better than God as to what we truly need. As an aunt of mine who died recently said, "It's all a matter of trust." How true!