Ye know how through infirmity of the flesh I preached the gospel unto you at the first.
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It seems probable that when Paul was blinded on the Damascus road and subsequently healed at the hands of Ananias, the healing was partial and his eyes continued to give him ongoing trouble. This is strongly hinted at in the immediate context of Gal 4:13; in v 15, Paul says that had it been possible, the Galatians would have plucked out their own eyes and given them to him. But why would they have had such an inclination unless he had difficulty with his eyes?
A further hint may be found in Gal 6:11, where (on the most probable interpretation) Paul notes the large size of the letters with which he is writing the closing section of the letter.